The formalin test does not probe inflammatory pain but excitotoxicity in rodent skin

T Hoffmann, F Klemm, TI Kichko, SK Sauer… - Physiological …, 2022 - Wiley Online Library
… used formalin test to screen antinociceptive drug candidates is … In addition, immediate paw
swelling, plasma extravasation … transient antinociceptive opioid effect but occurred delayed at …

Systemic administration of dorsomorphin relieves inflammatory nociception in the mouse formalin test

Y Xinqiang, J Yuanyuan, Y Zhipeng, K Jie… - International …, 2022 - Elsevier
… , thus we think that the antinociceptive effect of dorsomorphin is … before the CFA significantly
delayed the onset of the … In the present study, we found that formalin induced paw edema

Ulinastatin exhibits antinociception in rat models of acute somatic and visceral pain through inhibiting the local and central inflammation

MX Zhan, L Tang, YF Lu, HH Wu, ZB Guo… - Journal of Pain …, 2021 - Taylor & Francis
… Moreover, ip administration of ulinastatin was also able to delay the occurrence of … Display
full size … ulinastatin could also persistently inhibit formalin-induced paw edema and ulcer …

Anti-inflammatory and antinociceptive effects, and safety toxicological profile of a new paracetamol analog, LQFM291

LC Turones, LS Machado, BG Vaz… - …, 2023 - Springer
… paracetamol showed a similar antinociceptive effect in formalin test compared to LQFM291.
… and edema tests were performed, paracetamol showed a delayed antinociceptive and anti-…

[HTML][HTML] … of Cajanus cajan (L) Millsp. produced antinociceptive and anti-inflammatory actions through inhibition of inflammatory mediators and activation of opioidergic …

TG Olubodun-Obadun, IO Ishola, CA Osumuo… - Phytomedicine Plus, 2023 - Elsevier
… the early and late phases of formalin-induced inflammatory pain… , we did not observe any
sign of toxic behaviour nor delayed … In this study, the oedema formation was maximal at 5 h after …

Antinociceptive effects of gamma-linolenic acid in the formalin test in the rats

K Rahimi, A Nourishirazi, H Delaviz… - … of Medicine and …, 2024 - journals.lww.com
… as formalin into the peripheral region, cell migration, oedema… effective in reducing the
pain intensity in the formalin test. It … The c-Fos gene is an immediate-early gene that is rapidly …

The annonalide diterpene extracted from Casimirella ampla (Miers) reduces inflammatory and antinociceptive events in general models of inflammation

…, DFP Vasconcelos, EB do Nascimento Junior… - Journal of …, 2024 - Elsevier
… our previous results on paw edema. Otherwise, the formalin test is triggered by the high …
system during the first phase, characterizing neurogenic pain, while the inflammatory …

The antinociceptive effect of adalimumab, a TNF-alpha inhibitor, in a mice model of inflammatory pain

ÖZ Mehmet, H Şimşek - Türk Doğa ve Fen Dergisi, 2020 - dergipark.org.tr
… pulmonary edema and histological damage due to … This test is based on recording the
delay in the experimental … adalimumab has an antinociceptive effect in the formalin test. …

Neo-clerodane diterpenic influence in the antinociceptive and anti-inflammatory properties of Salvia circinnata Cav.

MP Fernando, HL Alberto, VDM Guadalupe… - Journal of …, 2021 - Elsevier
… using the plantar test and carrageenan-induced edema. The … was a beam emitted by a
caloric source with an intensity of … treatments in the formalin test in contrast to a delay of almost …

Saffron (Crocus sativus) and its constituents for pain management: A review of current evidence

AM Pourbagher‐Shahri… - Phytotherapy Research, 2023 - Wiley Online Library
… Saffron showed antinociceptive activities in formalin-, … , xylene-induced ear edema, and
formalin-induced inflammation to … , and weightlifting can lead to delayed-onset muscle soreness (…